Debbie Wilkins escapes from Hollywood and heads east to Oklahoma City to link up with her older sister Fran after she is released from an insane asylum for her murder spree on the set of "The Bayou Butcher" in Axe to Grind. Soon after their reunion, the two sisters embark on a wild and bloody cross country road trip to evade law enforcement after Debbie does away with her parole officer. Meanwhile, Rikki, the younger sister of Nikki who Debbie dispatched of in the first movie, elicits information from Debbie's old flame Peter Burgess in order to track down Debbie and exact her revenge.

B-movie legend, actress Debbie Wilkins, has just been replaced by a 23 yr old scream queen in her lovers bed. More importantly she's been left out of her lovers new film. Debbie doesn't take rejection well.

People from various walks of life find themselves held captive in a desolate area surrounding a secret government installation rumored to contain extraterrestrial life