A police officer who is diagnosed with Alzheimer's disease must solve one last case before he loses all his memories. He must run against time to catch the notorious serial killer who he believes has a mysterious role in his own personal life.

Venky, suspected of committing multiple murders, suffers from memory loss and finds himself entangled in a web of lies. However, the true identity of Venky and the person responsible for his predicament are complex and multi-layered, leading to the discovery of the real killer.

In a state where we grew up admiring how coach Nambiar and his protégé Usha brought back athletic glory in truckloads, Kho Kho is a highly relatable tale of a talented athlete transferring her spark of desire onto the next generation.