Reina of the West is a western drama that chronicles the life of a black woman, Reina, who is forced to find a path of survival after her family abandons her. Finding other women with similar fates as her own, abandoned or outcast, Reina starts a ranch under the guise of a man's name but when a group of men in town get jealous of her ranch's success they devise a plan to shut down the ranch. Reina and her female ranch hands set out on a path to save their ranch but it also leads Reina down a road that forces her to face parts of her past that she hasn't truly come to terms with.

Noah, an aimless college dropout, is constantly getting swept up in romances that always end in heartbreak. At work, he is paired to train Autumn, an infectious, enigmatic and fun new girl, who challenges his views on love, relationships and life.