In the 1940s, Anna, Doris, and Ditas are patients afflicted with Hansen’s Disease (or widely known as leprosy) who live in Culion at a time when the disease is practically a life sentence. No cure has yet been found, and no one is allowed to leave.

A freelance videographer, a rookie police officer, an undercover PDEA agent, and a crime-in-progress. Only tonight, a comet flies over Manila and the cosmic disturbances turn everything on its head for one night. Everything that could go wrong suddenly foes right.

After getting busted for having an affair with a married woman, Sonny, a gym instructor, crashes in with his friend Lito along with three other working guys: Ben, Mario, and Roy. They all share an apartment in Manila to make ends meet as Mario and Lito both work as call center agents, Ben as a restaurant waiter, and Roy as a bartender. Sonny’s supposed brief stay will reveal long kept secrets among the roommates, and will test their friendship. Will their responsibilities as men outweigh the joy they get from their relationships with each other and the women in their lives?

Liezl, an ambitious agent, learns that her colleague, Susanah, uses her body to sell condo units; so she imitates her scheme. When the tables turn, Liezl begins to face her punishments one by one.

Desperate to provide a comfortable life for her children, Ina willingly takes all kinds of jobs available to her. But what happens when Ina's family continues to fall apart despite all her sacrifices?

Sarah is a young woman with the gift of seeing and hearing things before they happen. As a child, she sees her father’s death before it happens.