After Lettie arrives in Chicago from a cross-country train ride, a local newspaper reporter asks to interview her to talk about her beloved devotional, Streams in the Desert, and her lifelong devotion to missions. As Lettie shares about her missionary work in the Orient with her husband Charles, Lettie reflects on how their big goals to reach every person in Japan are interrupted when Charles becomes ill and the two are forced to return home. During the decline of her husband’s health, Lettie begins writing a journal as the Lord gives her and Charles encouragement from the Bible and the library of books they had collected through their work. Little did they know that the journal would become the most beloved Christian devotional of all time, and their missionary work would continue to this day in over fifty countries on six continents.