Knockouts Knockdown was a professional wrestling event produced by Impact Wrestling. It was taped on September 17, 2021 at Skyway Studios in Nashville, Tennessee, and aired on October 9, 2021 on Impact Plus. It was the sixth event in the Knockouts Knockdown chronology, the first event to be held since 2017, and the first to be held since the discontinuation of Impact's One Night Only series in 2019.